منابع مشابه
Exercise and the Aging Endothelium
The endothelium plays a critical role in the maintenance of cardiovascular health by producing nitric oxide and other vasoactive materials. Aging is associated with a gradual decline in this functional aspect of endothelial regulation of cardiovascular homeostasis. Indeed, age is an independent risk factor for cardiovascular diseases and is in part an important factor in the increased exponenti...
متن کاملMini Review Aging and the endothelium
One link between aging and endothelial function is the inflammatory response. On one hand, the latter shortens the biological engaged by activated leukocytes against invaders or stressing agents. On the other hand, the surveyed tissues become targets of the toxicity of reactive oxygen species, ROS. The ensuing regeneration is source of transcriptional infidelity, leading to the alteration of th...
متن کاملEndothelium Aging and Vascular Diseases
Aging is a biological process that causes a progressive deterioration of structure and func‐ tion of all organs over the time [1]. According to the United Nation’s report, the number of people aged 60 and over in the world has increased from 8% (200 million) in 1950 to 11% (760 million) in 2005, and it is estimated that this number will further increase to 22% (2 bil‐ lion) in 2050. It is expec...
متن کاملThe Endothelium Abridges Insulin Resistance to Premature Aging
A lthough there are different mechanistic theories for aging, endothelial dysfunction (ED) is a rather neglected player in the aging process. A maladaptive insulin/IGF-1-like signaling (IIS) has a remarkable importance in proaging mechanisms, and insulin has direct effects on ED. Therefore, we assume that the endothelium plays a key role in mediating the aging process in the presence of maladap...
متن کاملAging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles.
Blood flow capacity in skeletal muscle declines with age. Reduced blood flow capacity may be related to decline in the maximal vasodilatory capacity of the resistance vasculature. This study tested the hypothesis that aging results in impaired vasodilatory capacity of first-order (1A) arterioles isolated from rat-hindlimb locomotory muscle: 1A arterioles (90-220 microm) from gastrocnemius and s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Vascular Biology
سال: 2021
ISSN: 2516-5658
DOI: 10.1530/vb-20-0013